Article

Genetic mapping of APP and amyloid-β biology modulation by trisomy 21

2022-03-12

Abstract excerpt

Individuals who have Down syndrome frequently develop early onset Alzheimer’s disease, a neurodegenerative condition caused by the build-up of aggregated amyloid-β and tau proteins in the brain. Amyloid-β is produced by APP, a gene located on chromosome 21. People who have Down syndrome have three copies of chromosome 21 and thus also an additional copy of APP ; this genetic change drives the early development o...

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Literature Corpus work: f04b490c-9543-5377-a5b4-151be503da89
DOI: 10.1101/2022.03.10.483782

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