Article

A nuclear branched-chain amino acid catabolism pathway controls histone propionylation in pancreatic cancer

2025-04-26

Abstract excerpt

<h4>ABSTRACT</h4> Branched-chain amino acid (BCAA) catabolism contributes prominently to the TCA cycle in the healthy pancreas but is suppressed in pancreatic ductal adenocarcinoma (PDA). The impact of this metabolic remodeling on cancer phenotypes remains poorly understood. Here, we find that the BCAA isoleucine is a primary source of propionyl-CoA in PDA cells. Reduction of propionyl-CoA availability by either...

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Identifiers and source

Literature Corpus work: d8ef11d8-ac16-5585-b837-81a3430313c3
DOI: 10.1101/2025.04.23.650241

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