Article

A cancer cell-intrinsic GOT2-PPARδ axis suppresses antitumor immunity

2020-12-26

Abstract excerpt

Despite significant recent advances in precision medicine 1,2 , pancreatic ductal adenocarcinoma (PDAC) remains near-uniformly lethal. While the most frequent genomic alterations in PDAC are not presently druggable 3 and conventional therapies are often ineffective in this disease 4 , immune-modulatory therapies hold promise to meaningfully improve outcomes for PDAC patients. Development of such therapies requi...

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Literature Corpus work: 2be388ee-b723-5755-86f8-08e83f0498c7
DOI: 10.1101/2020.12.25.424393

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