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Article

Depletion of potential A2M risk haplotype for Alzheimer's disease in long-lived individuals.

European journal of human genetics : EJHG - 1 Jan 2010

Flachsbart Friederike, Caliebe Amke, Nothnagel Michael, Kleindorp Rabea, Nikolaus Susanna, Schreiber Stefan, Nebel Almut

Abstract excerpt

Risk alleles for age-related diseases are expected to decrease in frequency in the population strata of increasing age. Consistent with this hypothesis, earlier studies showed a depletion of the Alzheimer's disease risk factor APOE*epsilon4 in long-lived individuals (LLIs). To evaluate whether this observation also holds for a previously suggested Alzheimer's disease risk haplotype in the A2M gene, we analyzed...

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Identifiers

PMID: 19639019
DOI: 10.1038/ejhg.2009.136
PMCID: PMC2987169

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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