Article

Contributions of hyperactive mutations in M <sup>pro</sup> from SARS-CoV-2 to drug resistance

2023-09-29

Abstract excerpt

The appearance and spread of mutations that cause drug resistance in rapidly evolving diseases, including infections by SARS-CoV-2 virus, are major concerns for human health. Many drugs target enzymes, and resistance-conferring mutations impact inhibitor binding and/or enzyme activity. Nirmatrelvir, the most widely used inhibitor currently used to treat SARS-CoV-2 infections, targets the main protease (M pro ) pr...

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Literature Corpus work: d8de29d1-a2f9-57e1-aca8-c12735c3828b
DOI: 10.1101/2023.09.28.560010

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