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Naturally Occurring Mutations of SARS-CoV-2 Main Protease Confer Drug Resistance to Nirmatrelvir

24 Jul 2023

Abstract excerpt

High Resolution Image Download MS PowerPoint Slide The SARS-CoV-2 main protease (M pro ) is the drug target of Pfizer’s oral drug nirmatrelvir. The emergence of SARS-CoV-2 variants with mutations in M pro raised the alarm of potential drug resistance. To identify potential clinically relevant drug-resistant mutants, we systematically characterized 102 naturally occurring M pro mutants located at 12 residues at...

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PMID: 37637734
DOI: 10.1021/acscentsci.3c00538

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