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A SARS-CoV-2 Mpro mutation conferring ensitrelvir resistance paradoxically increases nirmatrelvir susceptibility

2025-04-21

Abstract excerpt

<title>Abstract</title> <p>SARS-CoV-2 variants resistant to current antivirals remain a significant threat, particularly in high-risk patients. Although nirmatrelvir and ensitrelvir both target the viral 3CL protease (M<sup>pro</sup>), their distinct susceptibility profiles may allow alternative therapeutic approaches. Here, we identified a novel deletion mutation at glycine 23 (Δ23G) in M<sup>pro</sup> that conf...

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Literature Corpus work
ae27636c-5e9b-55ce-8456-3a122bf596f2
DOI
10.21203/rs.3.rs-6449068/v1
Open publication

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