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Systematic analyses of the resistance potential of drugs targeting SARS-CoV-2 main protease

2023-03-02

Abstract excerpt

Drugs that target the main protease (M pro ) of SARS-CoV-2 are effective therapeutics that have entered clinical use. Wide-scale use of these drugs will apply selection pressure for the evolution of resistance mutations. To understand resistance potential in M pro , we performed comprehensive surveys of amino acid changes that can cause resistance in a yeast screen to nirmatrelvir (contained in the drug Paxlovid...

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Literature Corpus work
58770d62-445e-5ad6-8e22-d56548217820
DOI
10.1101/2023.03.02.530652
Open publication

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