Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comprehensive fitness landscape of SARS-CoV-2 Mpro reveals insights into viral resistance mechanisms

20 Jun 2022

Abstract excerpt

With the continual evolution of new strains of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) that are more virulent, transmissible, and able to evade current vaccines, there is an urgent need for effective anti-viral drugs. The SARS-CoV-2 main protease (M pro ) is a leading target for drug design due to its conserved and indispensable role in the viral life cycle. Drugs targeting M pro appear...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Computational Drug Discovery Methods
Share to SARS-CoV-2 and COVID-19 Research
Share to vaccines and immunoinformatics approaches

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35723575
DOI: 10.7554/elife.77433

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comprehensive fitness landscape of SARS-CoV-2 Mpro reveals insights into viral resistance mechanismsPMID 35723575Read ↗

Comprehensive fitness landscape of SARS-CoV-2 M <sup>pro</sup> reveals insights into viral resistance mechanismsSemantic proximity Read ↗

The Functional Landscape of SARS-CoV-2 3CL ProteaseSemantic proximity Read ↗

Contributions of hyperactive mutations in M <sup>pro</sup> from SARS-CoV-2 to drug resistanceSemantic proximity Read ↗

A strategy for evaluating potential antiviral resistance to small molecule drugs and application to SARS-CoV-2.Semantic proximity Read ↗

SARS-CoV-2 main protease (M-pro) mutational profiling: An insight into mutation coldspots.Semantic proximity Read ↗

Contributions of Hyperactive Mutations in Mpro from SARS-CoV-2 to Drug Resistance.Semantic proximity Read ↗

Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistanceSemantic proximity Read ↗

Biochemical features and mutations of key proteins in SARS-CoV-2 and their impacts on RNA therapeutics.Semantic proximity Read ↗

A yeast-based system to study SARS-CoV-2 M <sup>pro</sup> structure and to identify nirmatrelvir resistant mutationsSemantic proximity Read ↗

Evolution of the SARS-CoV-2 main protease under fitness constraints imposed by folding stability and activitySemantic proximity Read ↗

Sequence characterization and molecular modeling of clinically relevant variants of the SARS-CoV-2 main proteaseSemantic proximity Read ↗

A yeast-based system to study SARS-CoV-2 Mpro structure and to identify nirmatrelvir resistant mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.