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Article

Naturally occurring mutations of SARS-CoV-2 main protease confer drug resistance to nirmatrelvir

2022-06-28

Abstract excerpt

<h4>ABSTRACT</h4> The SARS-CoV-2 main protease (M pro ) is the drug target of Pfizer’s oral drug Paxlovid. The emergence of SARS-CoV-2 variants with mutations in M pro raised the alarm of potential drug resistance. In this study, we identified 100 naturally occurring M pro mutations located at the nirmatrelvir binding site, among which 20 mutants, including S144M/F/A/G/Y, M165T, E166G, H172Q/F, and Q192T/S/L/A...

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Literature Corpus work
a3911d4c-11ea-5f06-9698-98c39dec0141
DOI
10.1101/2022.06.28.497978
Open publication

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Naturally occurring mutations of SARS-CoV-2 main protease confer drug resistance to nirmatrelvirDOI 10.1101/2022.06.28.497978
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