Article

Comprehensive fitness landscape of SARS-CoV-2 M <sup>pro</sup> reveals insights into viral resistance mechanisms

2022-01-26

Abstract excerpt

With the continual evolution of new strains of SARS-CoV-2 that are more virulent, transmissible, and able to evade current vaccines, there is an urgent need for effective anti-viral drugs. SARS-CoV-2 main protease (M pro ) is a leading target for drug design due to its conserved and indispensable role in the viral life cycle. Drugs targeting M pro appear promising but will elicit selection pressure for resistanc...

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Literature Corpus work: 9a4a40ff-3172-5b12-8e32-f680162626ae
DOI: 10.1101/2022.01.26.477860

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