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Article

Colorectal cancer landscape from gut microbiota: Insights into mutations, epigenetic dysregulation, and immune microenvironment alterations.

Virulence - 1 Dec 2026

Li Yunze, Yang Ying, Zhang Xixia, Huang Zhe, Zhang Xiaoyue, Wen Junxiong

Abstract excerpt

This review explores how gut microbiota reshapes colorectal cancer (CRC) molecular landscape, driving initiation/progression via key mechanisms. Microbes/metabolites cause driver mutations (DNA damage, signaling interference) and alter epigenetics (DNA methylation, histone modifications, ncRNAs) to boost tumor cell proliferation/survival. Dysbiosis disrupts tumor immune microenvironment (TIME) by impairing immune...

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Identifiers

PMID: 42433082
DOI: 10.1080/21505594.2026.2696642
PMCID: PMC13360637

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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