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Article

The conserved RNA recognition motif and C3H1 domain of the Not4 ubiquitin ligase regulate in vivo ligase function.

Scientific reports - 25 May 2018

Chen Hongfeng, Sirupangi Tirupataiah, Wu Zhao-Hui, Johnson Daniel L, Laribee R Nicholas

Abstract excerpt

The Ccr4-Not complex controls RNA polymerase II (Pol II) dependent gene expression and proteasome function. The Not4 ubiquitin ligase is a Ccr4-Not subunit that has both a RING domain and a conserved RNA recognition motif and C3H1 domain (referred to as the RRM-C domain) with unknown function. We demonstrate that while individual Not4 RING or RRM-C mutants fail to replicate the proteasomal defects found in Not4...

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Identifiers

PMID: 29802328
DOI: 10.1038/s41598-018-26576-1
PMCID: PMC5970261

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