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Effects of the Hypomethylating Agent Guadecitabine on Peripheral Blood Mononuclear Cell Methylomes and Immune Cell Populations in Small-Cell Lung Cancer Patients

2026-02-19

Abstract excerpt

<h4>Background</h4> Small-cell lung cancer (SCLC) represents 15% of lung cancers and with a 5-year survival rate under 7% remains one of the deadliest malignancies. Although initially responsive to chemotherapy, rapid recurrence and resistance are common. Epigenetic modifications, particularly DNA methylation, contribute to tumor progression and therapy resistance. Guadecitabine, a hypomethylating agent (HMA), ha...

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Literature Corpus work
d8be377c-74be-5577-8a87-2328ef6e423a
DOI
10.64898/2026.02.18.706553
Open publication

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