Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Plasma cell-free DNA hydroxymethylation profiling reveals anti-PD-1 treatment response and resistance biology in non-small cell lung cancer

1 Jan 2024

Abstract excerpt

BACKGROUND: Treatment with immune checkpoint inhibitors (ICIs) targeting programmed death-1 (PD-1) can yield durable antitumor responses, yet not all patients respond to ICIs. Current approaches to select patients who may benefit from anti-PD-1 treatment are insufficient. 5-hydroxymethylation (5hmC) analysis of plasma-derived cell-free DNA (cfDNA) presents a novel non-invasive approach for identification of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Cancer Immunotherapy and Biomarkers
Share to Epigenetics and DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38212123
DOI: 10.1136/jitc-2023-008028

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Plasma cell-free DNA hydroxymethylation profiling reveals anti-PD-1 treatment response and resistance biology in non-small cell lung cancerPMID 38212123Read ↗

Blood-based Genomic and Cellular Determinants of Response to Neoadjuvant PD-1 Blockade in Patients with Non-Small-Cell Lung CancerSemantic proximity Read ↗

Genome-wide identification of differentially methylated promoters and enhancers associated with response to anti-PD-1 therapy in non-small cell lung cancerSemantic proximity Read ↗

Pilot study demonstrating changes in DNA hydroxymethylation enable detection of multiple cancers in plasma cell-free DNASemantic proximity Read ↗

Genomic hypomethylation in cell-free DNA predicts responses to checkpoint blockade in lung and breast cancerSemantic proximity Read ↗

Longitudinal monitoring of cell-free DNA methylation in ALK-positive non-small cell lung cancer patientsSemantic proximity Read ↗

5-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stagesSemantic proximity Read ↗

Effects of the Hypomethylating Agent Guadecitabine on Peripheral Blood Mononuclear Cell Methylomes and Immune Cell Populations in Small-Cell Lung Cancer PatientsSemantic proximity Read ↗

Plasma Exosomal DNA Methylation Profiles and Therapeutic Response in Non-Small Cell Lung CancerSemantic proximity Read ↗

5-hydroxymethylcytosine Profilings in Circulating Cell-free DNA as diagnostic biomarkers for DLBCLSemantic proximity Read ↗

Cell-free Tumor Methylome Analysis of Small Cell Lung Cancer Patients Identifies Subgroups with Prognostic AssociationsSemantic proximity Read ↗

Plasma cell-free DNA methylome profiling in pre- and post-surgery oral cavity squamous cell carcinomaSemantic proximity Read ↗

A Precision Epigenetic Approach to Non-Invasive Lung Cancer Screening Using Gene- Specific cfDNA MethylationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.