Article

DNA methylation status classifies pleural mesothelioma cells according to their immune profile: implication for precision epigenetic therapy

2024-08-09

Abstract excerpt

<h4>Background</h4> co-targeting of immune checkpoint inhibitors (ICI) CTLA-4 and PD-1 has recently become the new first-line standard of care therapy of pleural mesothelioma (PM) patients, with a significant improvement of overall survival over conventional chemotherapy. The analysis by tumor histotype demonstrated a greater efficacy of ICI therapy in non-epithelioid (non-E) vs epithelioid (E) PM; although some...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0d2e4a50-05a2-596d-81f8-9d8bfd88da9a
DOI: 10.1101/2024.08.08.607174

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

DNA methylation status classifies pleural mesothelioma cells according to their immune profile: implication for precision epigenetic therapyDOI 10.1101/2024.08.08.607174Read

DNA methylation status classifies pleural mesothelioma cells according to their immune profile: implication for precision epigenetic therapySemantic proximity Read

Integrative transcriptome analysis of malignant pleural mesothelioma reveals a clinically relevant immune-based classificationSemantic proximity Read

Disentangling heterogeneity of Malignant Pleural Mesothelioma through deep integrative omics analysesSemantic proximity Read

DNA Methylation Profiling Discriminates between Malignant Pleural Mesothelioma and Neoplastic or Reactive Histologic MimicsSemantic proximity Read

Multiomic analysis of malignant pleural mesothelioma identifies molecular axes and specialized tumor profiles driving intertumor heterogeneitySemantic proximity Read

Immune Microenvironment and Genetics in Malignant Pleural MesotheliomaSemantic proximity Read

Epigenetic Profiles Distinguish Malignant Pleural Mesothelioma from Lung AdenocarcinomaSemantic proximity Read

Targeting the epigenome in malignant pleural mesotheliomaSemantic proximity Read

BAP1 haploinsufficiency predicts a distinct immunogenic class of malignant peritoneal mesotheliomaSemantic proximity Read

Integrated multi-omics profiling reveals the role of the DNA methylation landscape in shaping biological heterogeneity and clinical behaviour of metastatic melanomaSemantic proximity Read

BAP1 Loss Predicts Therapeutic Vulnerability in Malignant Peritoneal MesotheliomaSemantic proximity Read

Integrative Molecular Characterization of Malignant Pleural Mesothelioma.Semantic proximity Read