Article

Systemic Effects of Missense Mutations on SARS-CoV-2 Spike Glycoprotein Stability and Receptor Binding Affinity

2020-05-22

Abstract excerpt

<h4>ABSTRACT</h4> The spike (S) glycoprotein of SARS-CoV-2 is responsible for the binding to the permissive cells. The receptor-binding domain (RBD) of SARS-CoV-2 S protein directly interacts with the human angiotensin-converting enzyme 2 (ACE2) on the host cell membrane. In this study, we used computational saturation mutagenesis approaches, including structure-based energy calculations and sequence-based pathog...

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Literature Corpus work: c4989936-d7a7-5a8e-b56b-8b1b35d52abe
DOI: 10.1101/2020.05.21.109835

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