Article

Nexus Between PI3K/AKT and Estrogen Receptor Signaling in Breast Cancer

2020-12-28

Abstract excerpt

Signaling from estrogen receptor alpha (ER) and its ligand estradiol (E2) is critical for growth of ~70% of breast cancers. Therefore, several drugs that inhibit ER functions are in clinical use for decades and new classes of anti-estrogens are continuously being developed. Although a significant number of ER+ breast cancers respond to anti-estrogen therapy, ~30% of these breast cancers recur, sometimes even af...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d8b48685-9cdd-5935-9398-225f2e6c4f1b
DOI: 10.20944/preprints202012.0675.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Nexus Between PI3K/AKT and Estrogen Receptor Signaling in Breast CancerDOI 10.20944/preprints202012.0675.v1Read

Targeting the PI3K/AKT/mTOR Pathway in Hormone-Positive Breast Cancer.Semantic proximity Read

Mechanism of resistance to endocrine therapy in breast cancer: the important role of PI3K/Akt/mTOR in estrogen receptor-positive, HER2-negative breast cancer.Semantic proximity Read

Crosstalk between the Estrogen Receptor and the HER Tyrosine Kinase Receptor Family: Molecular Mechanism and Clinical Implications for Endocrine Therapy ResistanceSemantic proximity Read

Targeted therapies for ER+/HER2- metastatic breast cancerSemantic proximity Read

Metastatic ER+ Breast Cancer: Mechanisms of Resistance and Future Therapeutic ApproachesSemantic proximity Read

Resistance to endocrine therapy in breast cancer: molecular mechanisms and future goalsSemantic proximity Read

Molecular Mechanisms and Therapeutic Strategies to Overcome Resistance to Endocrine Therapy and CDK4/6 Inhibitors in Advanced ER+/HER2- Breast CancerSemantic proximity Read

Estrogen Receptor Signaling in Breast CancerSemantic proximity Read

Molecular Changes During Breast Cancer and Mechanisms of Endocrine Therapy Resistance.Semantic proximity Read

Signal Transduction Pathways in Breast Cancer: The Important Role of PI3K/Akt/mTORSemantic proximity Read

Endocrine resistance in breast cancer--An overview and update.Semantic proximity Read

Biology and therapeutic potential of PI3K signaling in ER+/HER2-negative breast cancer.Semantic proximity Read