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Article

Biology and therapeutic potential of PI3K signaling in ER+/HER2-negative breast cancer.

Breast (Edinburgh, Scotland) - 1 Aug 2013

Fu Xiaoyong, Osborne C Kent, Schiff Rachel

Abstract excerpt

PI3K is a central node mediating growth factor receptor signaling. With its downstream effectors such as AKT and mTOR, and its crosstalk with the RAS/RAF/MEK/MAPK pathway, it plays a vital role in cancer cell proliferation, metabolism, and survival. Recent breast cancer (BC) molecular portraits delineate PI3K as the most frequently altered pathway, with recurrent PIK3CA mutations mostly found in the luminal...

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Share to Class I Phosphatidylinositol 3-Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24011769
DOI: 10.1016/j.breast.2013.08.001
PMCID: PMC3808116

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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