Article

Disruption of the Blood-Brain Barrier in 22q11.2 Deletion Syndrome

2019-11-14

Abstract excerpt

<h4>ABSTRACT</h4> Neuroimmune dysregulation is implicated in neuropsychiatric disorders including schizophrenia (SZ). As the blood brain barrier (BBB) is the immunological interface between the brain and the periphery, we investigated whether the BBB is intrinsically compromised in the most common genetic risk factor for SZ, the hemizygous deletion of chromosome 22q11.2 (22qDS). BBB-like endothelium (iBBB) differ...

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Literature Corpus work: d8b31084-7b0a-5d9b-975b-2c9b877803ce
DOI: 10.1101/824987

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