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Soluble TREM2 Mediates Blood Brain Barrier Permeability through Astrocyte Reactivity

2026-08-27

Abstract excerpt

<title>Abstract</title> <p>The Triggering receptor expressed on myeloid cells 2 (TREM2) is a transmembrane protein predominantly expressed by cells of the myeloid lineage. In the CNS, it is mainly expressed by microglia and macrophages, where it regulates their reactive state. This protein can be shed to release soluble TREM2 (sTREM2), which is increased in the cerebrospinal fluid of people with neurocognitive di...

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Literature Corpus work: e882e64c-95c7-5666-8845-cdc99a20493a
DOI: 10.21203/rs.3.rs-10730833/v1

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