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A cell-based assay to discover inhibitors of SARS-CoV-2 RNA dependent RNA polymerase

21 Apr 2021

Abstract excerpt

Antiviral therapeutics is one effective avenue to control and end this devastating COVID-19 pandemic. The viral RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2 has been recognized as a valuable target of antivirals. However, the cell-free SARS-CoV-2 RdRp biochemical assay requires the conversion of nucleotide prodrugs into the active triphosphate forms, which regularly occurs in cells yet is a complicated...

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PMID: 33894278
DOI: 10.1016/j.antiviral.2021.105078

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