Article
Genetic, individual, and familial risk correlates of brain network controllability in major depressive disorder.
Molecular psychiatry - 1 Mar 2023
Hahn Tim, Winter Nils R, Ernsting Jan, Gruber Marius, Mauritz Marco J, Fisch Lukas, Leenings Ramona, Sarink Kelvin, Blanke Julian, Holstein Vincent, Emden Daniel, Beisemann Marie, Opel Nils, Grotegerd Dominik, Meinert Susanne, Heindel Walter, Witt Stephanie, Rietschel Marcella, Nöthen Markus M, Forstner Andreas J, Kircher Tilo, Nenadic Igor, Jansen Andreas, Müller-Myhsok Bertram, Andlauer Till F M, Walter Martin, van den Heuvel Martijn P, Jamalabadi Hamidreza, Dannlowski Udo, Repple Jonathan
Abstract excerpt
Many therapeutic interventions in psychiatry can be viewed as attempts to influence the brain's large-scale, dynamic network state transitions. Building on connectome-based graph analysis and control theory, Network Control Theory is emerging as a powerful tool to quantify network controllability-i.e., the influence of one brain region over others regarding dynamic network state transitions. If and how network...
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