Article

FOXO1 mitigates the SMAD3/FOXL2 <sup>C134W</sup> Transcriptomic Effect in a Model of Human Adult Granulosa Cell Tumor

2020-12-16

Abstract excerpt

<h4>Background</h4> Adult granulosa cell tumor (aGCT) is a rare type of stromal cell malignant cancer of the ovary characterized by elevated estrogen levels. aGCTs ubiquitously harbor a somatic mutation in FOXL2 gene, Cys134Trp (c.402C<G); however, the general molecular effect of this mutation and its putative pathogenic role in aGCT tumorigenesis is not completely understood. We previously studied the role of F...

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Literature Corpus work: d86fbbd8-b398-58e9-90f7-1cceb6c1ec8b
DOI: 10.1101/2020.12.15.422901

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