Article

The pathognomonic FOXL2 C134W mutation alters DNA binding specificity

2020-03-21

Abstract excerpt

The somatic missense point mutation c.402C>G (p.C134W) in the FOXL2 transcription factor is pathognomonic for adult-type granulosa cell tumours (AGCT) and a diagnostic marker for this tumour type. However, the molecular consequences of this mutation and its contribution to the mechanisms of AGCT pathogenesis remain unclear. To explore the mechanisms driving FOXL2 C134W pathogenicity we engineered V5-FOXL2 WT and...

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Literature Corpus work: 30487045-4a09-5b22-9e03-35b2ca4d00af
DOI: 10.1101/2020.03.20.984476

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