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Article

FOXO1 mitigates the SMAD3/FOXL2C134W transcriptomic effect in a model of human adult granulosa cell tumor.

Journal of translational medicine - 27 Feb 2021

Secchi Christian, Benaglio Paola, Mulas Francesca, Belli Martina, Stupack Dwayne, Shimasaki Shunichi

Abstract excerpt

BACKGROUND: Adult granulosa cell tumor (aGCT) is a rare type of stromal cell malignant cancer of the ovary characterized by elevated estrogen levels. aGCTs ubiquitously harbor a somatic mutation in FOXL2 gene, Cys134Trp (c.402C < G); however, the general molecular effect of this mutation and its putative pathogenic role in aGCT tumorigenesis is not completely understood. We previously studied the role of...

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Identifiers

PMID: 33639972
DOI: 10.1186/s12967-021-02754-0
PMCID: PMC7913442

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FOXO1 mitigates the SMAD3/FOXL2C134W transcriptomic effect in a model of human adult granulosa cell tumor.PMID 33639972Read ↗

FOXO1 mitigates the SMAD3/FOXL2 <sup>C134W</sup> Transcriptomic Effect in a Model of Human Adult Granulosa Cell TumorSemantic proximity Read ↗

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The Pathognomonic FOXL2 C134W Mutation Alters DNA-Binding SpecificitySemantic proximity Read ↗

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