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Article

Gain-of-Function Chromatin Remodeling Activity of Oncogenic FOXL2C134W Reprograms Glucocorticoid Receptor Occupancy to Drive Granulosa Cell Tumors.

Cancer research - 3 Mar 2025

Welte Thomas, Vuttaradhi Veena K, Khlebus Eleonora Y, Brodsky Allison, Flores Legarreta Alejandra, Celestino Joseph, Powell Reid T, Stephan Clifford C, Nguyen Nghi, Li Jian, Takamatsu Shiro, Calzoncinth Katherine, Sood Anil K, Gershenson David M, Futreal P Andrew, Lawson Barrett, Hillman R Tyler

Abstract excerpt

Adult type ovarian granulosa cell tumors (AGCT) are rare malignancies with the near universal c.C402G (p.Cys134Trp) somatic mutation in FOXL2, a forkhead box family transcription factor important for ovarian function. Relapsed AGCT is incurable, but the mechanism of the unique FOXL2 mutation could confer therapeutic vulnerabilities. To identify FOXL2C134W-dependent pharmacologic synergies, we created and...

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Share to Chromatin Assembly and Disassembly
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Forkhead Box Protein L2

Share to Gene Expression Regulation, Neoplastic

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Share to Ovarian Neoplasms

Share to Receptors, Glucocorticoid

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Source

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Identifiers

PMID: 39652611
DOI: 10.1158/0008-5472.CAN-24-2341
PMCID: PMC11873728

Genes

FOXL2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

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Research trail→

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Gain-of-Function Chromatin Remodeling Activity of Oncogenic FOXL2C134W Reprograms Glucocorticoid Receptor Occupancy to Drive Granulosa Cell Tumors.PMID 39652611Read ↗

The Pathognomonic FOXL2 C134W Mutation Alters DNA-Binding SpecificitySemantic proximity Read ↗

FOXO1 mitigates the SMAD3/FOXL2C134W transcriptomic effect in a model of human adult granulosa cell tumor.Semantic proximity Read ↗

FOXO1 mitigates the SMAD3/FOXL2 <sup>C134W</sup> Transcriptomic Effect in a Model of Human Adult Granulosa Cell TumorSemantic proximity Read ↗

The pathognomonic FOXL2 C134W mutation alters DNA binding specificitySemantic proximity Read ↗

Mutant FOXL2C134W Hijacks SMAD4 and SMAD2/3 to Drive Adult Granulosa Cell Tumors.Semantic proximity Read ↗

Mutation of FOXL2 in granulosa-cell tumors of the ovary.Semantic proximity Read ↗

The Oncogenic FOXL2 C134W Mutation Is a Key Driver of Granulosa Cell Tumors.Semantic proximity Read ↗

Adult ovarian granulosa cell tumor transcriptomics: prevalence of FOXL2 target genes misregulation gives insights into the pathogenic mechanism of the p.Cys134Trp somatic mutation.Semantic proximity Read ↗

Impact of FOXL2 mutations on signaling in ovarian granulosa cell tumors.Semantic proximity Read ↗

Adult-type granulosa cell tumor of the ovary: a FOXL2-centric disease.Semantic proximity Read ↗

Combined comparative genomic hybridization and transcriptomic analyses of ovarian granulosa cell tumors point to novel candidate driver genesSemantic proximity Read ↗

CRISPR targeting of FOXL2 c.402C>G mutation reduces malignant phenotype in granulosa tumor cells and identifies anti-tumoral compoundsSemantic proximity Read ↗

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