The Pathognomonic FOXL2 C134W Mutation Alters DNA-Binding Specificity

Abstract excerpt

Abstract The somatic missense point mutation c.402C>G (p.C134W) in the FOXL2 transcription factor is pathognomonic for adult-type granulosa cell tumors (AGCT) and a diagnostic marker for this tumor type. However, the molecular consequences of this mutation and its contribution to the mechanisms of AGCT pathogenesis remain unclear. To explore these mechanisms, we engineered V5-FOXL2WT- and V5-FOXL2C134W–inducible...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to FOXO transcription factor regulation
• Share to Ovarian cancer diagnosis and treatment