Evolvability of cancer-associated genes under APOBEC3A/B selection

Abstract excerpt

<h4>Summary</h4> Evolvability is an emergent hallmark of cancer that depends on intra-tumor heterogeneity and, ultimately, genetic variation. Mutations generated by APOBEC3 cytidine deaminases can contribute to genetic variation and the consequences of APOBEC activation differ depending on the stage of cancer, with the most significant impact observed during the early stages. However, how APOBEC activity shapes e...

Topics

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• Cancer Genomics and Diagnostics
• Carcinogenesis
• Computational Biology
• INDEL Mutation
• Microsatellite Instability
• Models, Genetic
• Mutation
• Neoplasms

Identifiers and source

Literature Corpus work

cf9cbff9-6551-5f58-ab65-231f4f281b98

DOI

10.1101/2023.08.27.554991