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Genome-Wide m6A Methylation Profiling Reveals Epitranscriptomic Dysregulation in Peripheral Blood Mononuclear Cells from Parkinson's Disease Patients

2026-08-07

Abstract excerpt

<title>Abstract</title> <p> Background Initial targeted assessments revealed a discordance in α-synuclein (α-syn) homeostasis in Parkinson's disease (PD), characterized by elevated plasma protein levels despite downregulated <italic>SNCA</italic> mRNA in peripheral blood mononuclear cells (PBMCs). This was accompanied by a significant downregulation of the m6A methyltransferase METTL14 and the reader proteins...

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Literature Corpus work
d85430c8-8f31-5cf8-8123-945d6bd66e53
DOI
10.21203/rs.3.rs-10535034/v1
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Genome-Wide m6A Methylation Profiling Reveals Epitranscriptomic Dysregulation in Peripheral Blood Mononuclear Cells from Parkinson's Disease PatientsDOI 10.21203/rs.3.rs-10535034/v1
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