Article
Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders.
Genome biology - 26 Mar 2021
Nabais Marta F, Laws Simon M, Lin Tian, Vallerga Costanza L, Armstrong Nicola J, Blair Ian P, Kwok John B, Mather Karen A, Mellick George D, Sachdev Perminder S, Wallace Leanne, Henders Anjali K, Zwamborn Ramona A J, Hop Paul J, Lunnon Katie, Pishva Ehsan, Roubroeks Janou A Y, Soininen Hilkka, Tsolaki Magda, Mecocci Patrizia, Lovestone Simon, Kłoszewska Iwona, Vellas Bruno, Furlong Sarah, Garton Fleur C, Henderson Robert D, Mathers Susan, McCombe Pamela A, Needham Merrilee, Ngo Shyuan T, Nicholson Garth, Pamphlett Roger, Rowe Dominic B, Steyn Frederik J, Williams Kelly L, Anderson Tim J, Bentley Steven R, Dalrymple-Alford John, Fowder Javed, Gratten Jacob, Halliday Glenda, Hickie Ian B, Kennedy Martin, Lewis Simon J G, Montgomery Grant W, Pearson John, Pitcher Toni L, Silburn Peter, Zhang Futao, Visscher Peter M, Yang Jian, Stevenson Anna J, Hillary Robert F, Marioni Riccardo E, Harris Sarah E, Deary Ian J, Jones Ashley R, Shatunov Aleksey, Iacoangeli Alfredo, van Rheenen Wouter, van den Berg Leonard H, Shaw Pamela J, Shaw Cristopher E, Morrison Karen E, Al-Chalabi Ammar, Veldink Jan H, Hannon Eilis, Mill Jonathan, Wray Naomi R, McRae Allan F
Abstract excerpt
BACKGROUND: People with neurodegenerative disorders show diverse clinical syndromes, genetic heterogeneity, and distinct brain pathological changes, but studies report overlap between these features. DNA methylation (DNAm) provides a way to explore this overlap and heterogeneity as it is determined by the combined effects of genetic variation and the environment. In this study, we aim to identify shared blood...
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