Article

Loss of RNF2 delays tumour development in BAP1-deficient mesothelioma

2024-04-27

Abstract excerpt

The tumour suppressor gene BAP1 is mutated in more than half of the malignant mesothelioma patients. This catalytic subunit of Polycomb repressive deubiquitinating (PR-DUB) complex, plays an important role in maintaining gene expression levels by deubiquitinating the PRC1-mediated histone H2A lysine 119 mono-ubiquitination (H2AK119ub1). Published studies report varying degrees of importance of H2AK119ub1 in Polyc...

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Literature Corpus work: d851cd95-e215-57c3-b32d-cd4bd6f2e26f
DOI: 10.1101/2024.04.26.591241

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