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Genetic screens reveal new targetable vulnerabilities in BAP1-deficient mesothelioma

18 Jan 2023

Abstract excerpt

More than half of patients with malignant mesothelioma show alterations in the BAP1 tumor-suppressor gene. Being a member of the Polycomb repressive deubiquitinating (PR-DUB) complex, BAP1 loss results in an altered epigenome, which may create new vulnerabilities that remain largely unknown. Here, we performed a CRISPR-Cas9 kinome screen in mesothelioma cells that identified two kinases in the...

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PMID: 36657447
DOI: 10.1016/j.xcrm.2022.100915

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