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Article

Melanin-concentrating hormone is a critical mediator of the leptin-deficient phenotype.

Proceedings of the National Academy of Sciences of the United States of America - 19 Aug 2003

Segal-Lieberman Gabriella, Bradley Richard L, Kokkotou Efi, Carlson Michael, Trombly Daniel J, Wang Xiaomei, Bates Sarah, Myers Martin G, Flier Jeffrey S, Maratos-Flier Eleftheria

Abstract excerpt

Energy homeostasis is regulated by a complex network involving peripheral and central signals that determine food intake and energy expenditure. Melanin-concentrating hormone (MCH) plays an essential role in this process. Animals treated with MCH develop hyperphagia and obesity. Ablation of the prepro-MCH gene leads to a lean phenotype, as does ablation of the rodent MCH receptor, MCHR-1. MCH is overexpressed in...

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Identifiers

PMID: 12897241
DOI: 10.1073/pnas.1633636100
PMCID: PMC187774

Genes

SCD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Melanin-concentrating hormone is a critical mediator of the leptin-deficient phenotype.PMID 12897241Read ↗

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