Article
Leptin and melanocortin signaling in the hypothalamus.
Vitamins and hormones - 1 Jan 2002
Bjørbaek Christian, Hollenberg Anthony N
Abstract excerpt
The regulation of body weight in humans is coordinated by the interplay between food intake and energy expenditure. The identification of the adipocyte-secreted hormone leptin as a key regulator on both of these processes has shed new light on the pathways involved in their regulation. Indeed, mutations in the gene's encoding leptin and its cognate receptor cause severe obesity in humans. Leptin's actions are...
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