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Three metabolic pathways replenishing the one-carbon pool collectively support growth and virulence of <i>Listeria monocytogenes</i>

2025-09-10

Abstract excerpt

The bacterium Listeria monocytogenes can grow in the cytoplasm of infected human cells, but there it relies on specific biosynthetic pathways for intracellular nutrient supply. We previously found that the glycine cleavage system (GCS) is needed for intracellular growth. The GCS decarboxylates glycine for generation of 1C-tetrahydrofolates (1C-THF), folate-dependent one carbon donors needed for biosynthesis of ot...

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Literature Corpus work
494c2f02-acf9-5126-ad64-2bd8a7df89e3
DOI
10.1101/2025.09.10.675311
Open publication

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Three metabolic pathways replenishing the one-carbon pool collectively support growth and virulence of <i>Listeria monocytogenes</i>DOI 10.1101/2025.09.10.675311
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