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Genetic basis of glycine and L-serine toxicity in <i>Staphylococcus aureus</i> and the case for glycine as an antibiotic adjuvant

2026-06-08

Abstract excerpt

<h4>ABSTRACT</h4> The toxicity of the amino acids glycine and L-serine at high concentrations in bacteria was discovered decades ago. In this work, we used deep transposon insertion sequencing (Tn-seq) experiments to determine the genes necessary to tolerate excess L-serine, diglycine or glycine in the human pathogen Staphylococcus aureus . Our results indicate that intracellular accumulation of specific counter...

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Literature Corpus work
60984ed7-9f18-5fa4-8dd6-c180379aeaf4
DOI
10.64898/2026.06.08.730841
Open publication

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Genetic basis of glycine and L-serine toxicity in <i>Staphylococcus aureus</i> and the case for glycine as an antibiotic adjuvantDOI 10.64898/2026.06.08.730841
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