Article

A short ERK5 isoform modulates nucleocytoplasmic shuttling of active ERK5 and associates with poor survival in breast cancer

2021-03-23

Abstract excerpt

<h4>Background</h4> The nucleocytoplasmic shuttling of ERK5 has gained recent attention as a regulator of its diverse roles in cancer progression but the exact mechanisms for this shuttling are still under investigation. <h4>Methods</h4> Using in vitro, in vivo and in silico studies, we investigated the roles of shorter ERK5 isoforms in regulating the nucleocytoplasmic shuttling of active phosphorylated-ERK5 (...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e314e14d-1b18-55da-b2fd-fe34036342c9
DOI: 10.1101/2021.03.23.436061

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A short ERK5 isoform modulates nucleocytoplasmic shuttling of active ERK5 and associates with poor survival in breast cancerDOI 10.1101/2021.03.23.436061Read

NEK5 Activity Regulates the Mesenchymal and Migratory Phenotype in Breast Cancer CellsSemantic proximity Read

Clinical Significance and Regulation of ERK5 Expression and Function in CancerSemantic proximity Read

NEK5 activity regulates the mesenchymal and migratory phenotype in breast cancer cells.Semantic proximity Read

ERK3/MAPK6 promotes triple-negative breast cancer progression through collective migration and EMT plasticitySemantic proximity Read

Whole transcriptome analysis reveals ELK3 as a key driver of metastasis through regulation of 3D migration and stemness in triple-negative breast cancer cellsSemantic proximity Read

The oncogenic kinase NEK2 regulates an RBFOX2-dependent pro-mesenchymal splicing program in triple-negative breast cancer cellsSemantic proximity Read

Stat5a is tyrosine phosphorylated and nuclear localized in a high proportion of human breast cancersSemantic proximity Read

Oncogenic signaling of MEK5-ERK5.Semantic proximity Read

The subcellular localization of IGFBP5 affects its cell growth and migration functions in breast cancer.Semantic proximity Read

Landscape of EGFR signaling network in human cancers: Biology and therapeutic response in relation to receptor subcellular locationsSemantic proximity Read

Molecular Mechanisms of Epithelial to Mesenchymal Transition Regulated by ERK5 Signaling.Semantic proximity Read

Differential Expression of TKS4 Isoforms and Their Role in Cellular Processes in Breast CancerSemantic proximity Read