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Long-Term Simulation of Microgravity Induces Changes in Gene Expression in Breast Cancer Cells

7 Jan 2023

Abstract excerpt

Microgravity changes the gene expression pattern in various cell types. This study focuses on the breast cancer cell lines MCF-7 (less invasive) and MDA-MB-231 (triple-negative, highly invasive). The cells were cultured for 14 days under simulated microgravity (s-µg) conditions using a random positioning machine (RPM). We investigated cytoskeletal and extracellular matrix (ECM) factors as well as focal adhesion...

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PMID: 36674696
DOI: 10.3390/ijms24021181

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