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Human Pluripotent Stem Cell-Derived Organoids as Models of Liver Disease

15 Jun 2020

Abstract excerpt

BACKGROUND & AIMS: There are few in vitro models for studying the 3-dimensional interactions among different liver cell types during organogenesis or disease development. We aimed to generate hepatic organoids that comprise different parenchymal liver cell types and have structural features of the liver, using human pluripotent stem cells. METHODS: We cultured H1 human embryonic stem cells (WA-01, passage 27-40)...

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PMID: 32553762
DOI: 10.1053/j.gastro.2020.06.010

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