Article

Scavenging dicarbonyls with 5’-O-pentyl-pyridoxamine increases HDL net cholesterol efflux capacity and attenuates atherosclerosis and insulin resistance

2019-02-02

Abstract excerpt

<h4>Objective</h4> Oxidative stress contributes to the development of insulin resistance (IR) and atherosclerosis. Peroxidation of lipids produces reactive dicarbonyls such as Isolevuglandins (IsoLG) and malondialdehyde (MDA) that covalently bind plasma/cellular proteins, phospholipids, and DNA leading to altered function and toxicity. We examined whether scavenging reactive dicarbonyls with 5’-O-pentyl-pyridoxam...

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Literature Corpus work: d81ecf24-ed3d-5645-a990-07334fa753d4
DOI: 10.1101/529339

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