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Article

Elimination of GD3 synthase improves memory and reduces amyloid-beta plaque load in transgenic mice.

Neurobiology of aging - 1 Nov 2009

Bernardo Alexandra, Harrison Fiona E, McCord Meghan, Zhao Jiali, Bruchey Aleksandra, Davies Sean S, Jackson Roberts L, Mathews Paul M, Matsuoka Yasuji, Ariga Toshio, Yu Robert K, Thompson Rebecca, McDonald Michael P

Abstract excerpt

Gangliosides have been shown to be necessary for beta-amyloid (Abeta) binding and aggregation. GD3 synthase (GD3S) is responsible for biosynthesis of the b- and c-series gangliosides, including two of the four major brain gangliosides. We examined Abeta-ganglioside interactions in neural tissue from mice lacking the gene coding for GD3S (St8sia1), and in a double-transgenic (APP/PSEN1) mouse model of Alzheimer's...

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Identifiers

PMID: 18258340
DOI: 10.1016/j.neurobiolaging.2007.12.022

Genes

APP
PSEN1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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