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Article

Gangliosides determine the amyloid pathology of Alzheimer's disease.

Neuroreport - 5 Aug 2009

Oikawa Naoto, Yamaguchi Haruyasu, Ogino Koichi, Taki Takao, Yuyama Kohei, Yamamoto Naoki, Shin Ryong-Woon, Furukawa Koichi, Yanagisawa Katsuhiko

Abstract excerpt

Gangliosides, GM3 and GM1, are suggested to accelerate the deposition of the amyloid beta-protein as amyloid angiopathy and senile plaques, respectively, in the Alzheimer brain. We investigated the profile of amyloid deposition in the brains of transgenic mice expressing a mutant amyloid precursor protein with a disrupted GM2 synthase gene, in which GM3 accumulates whereas GM1 is lacking. These mice showed a...

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Identifiers

PMID: 19590389
DOI: 10.1097/WNR.0b013e32832e4b9d

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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