Article
Delineating Amyloid Plaque Associated Neuronal Sphingolipids in Transgenic Alzheimer's Disease Mice (tgArcSwe) Using MALDI Imaging Mass Spectrometry.
ACS chemical neuroscience - 15 Feb 2017
Kaya Ibrahim, Brinet Dimitri, Michno Wojciech, Syvänen Stina, Sehlin Dag, Zetterberg Henrik, Blennow Kaj, Hanrieder Jörg
Abstract excerpt
The major pathological hallmarks of Alzheimer's disease (AD) are the progressive aggregation and accumulation of beta-amyloid (Aβ) and hyperphosphorylated tau protein into neurotoxic deposits. Aβ aggregation has been suggested as the critical early inducer, driving the disease progression. However, the factors that promote neurotoxic Aβ aggregation remain elusive. Imaging mass spectrometry (IMS) is a powerful...
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