Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SOST/Sclerostin Improves Posttraumatic Osteoarthritis and Inhibits MMP2/3 Expression After Injury.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jun 2018

Chang Jiun C, Christiansen Blaine A, Murugesh Deepa K, Sebastian Aimy, Hum Nicholas R, Collette Nicole M, Hatsell Sarah, Economides Aris N, Blanchette Craig D, Loots Gabriela G

Abstract excerpt

Patients with anterior cruciate ligament (ACL) rupture are two times as likely to develop posttraumatic osteoarthritis (PTOA). Annually, there are ∼900,000 knee injuries in the United States, which account for ∼12% of all osteoarthritis (OA) cases. PTOA leads to reduced physical activity, deconditioning of the musculoskeletal system, and in severe cases requires joint replacement to restore function. Therefore,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Morphogenetic Proteins
Share to Extracellular Matrix

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glycoproteins

Share to Intercellular Signaling Peptides and Proteins

Share to Matrix Metalloproteinase 2

Share to Matrix Metalloproteinase 3

Share to NF-kappa B

Share to Osteoarthritis, Knee

Source

Open in PubMed Open full text

Identifiers

PMID: 29377313
DOI: 10.1002/jbmr.3397
PMCID: PMC6033030

Genes

SOST
MMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SOST/Sclerostin Improves Posttraumatic Osteoarthritis and Inhibits MMP2/3 Expression After Injury.PMID 29377313Read ↗

Does Sclerostin Depletion Stimulate Fracture Healing in a Mouse Model?Semantic proximity Read ↗

Antibiotic Treatment Prior to Injury Improves Post-Traumatic Osteoarthritis Outcomes in Mice.Semantic proximity Read ↗

Comparative Transcriptomics Identifies Novel Genes and Pathways Involved in Post-Traumatic Osteoarthritis Development and ProgressionSemantic proximity Read ↗

Molecular Mechanism Study of Medial Open-Wedge High Tibial Osteotomy in Treating Medial Compartment Osteoarthritis of the Knee by Improving the Intra-Articular EnvironmentSemantic proximity Read ↗

Hippo Signaling Modulates the Inflammatory Response of Chondrocytes to Mechanical Compressive LoadingSemantic proximity Read ↗

Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength.Semantic proximity Read ↗

Sexual dimorphism of the synovial transcriptome underpins greater PTOA disease severity in male mice following joint injurySemantic proximity Read ↗

Global molecular changes in a tibial compression induced ACL rupture model of post-traumatic osteoarthritis.Semantic proximity Read ↗

Cell Biology of Knee Joint Injuries: Early Mechanical Loading PerspectiveSemantic proximity Read ↗

Posttraumatic osteoarthritis: what have we learned to advance osteoarthritis?Semantic proximity Read ↗

Osteoarthritis: Trauma vs Disease.Semantic proximity Read ↗

A standardized, open-source, portable model for noninvasive joint injury in miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.