Article

Limited roles of Piezo mechanosensing channels in articular cartilage development and osteoarthritis progression

2022-10-08

Abstract excerpt

Osteoarthritis (OA) is a prevalent disease characterized by degeneration of the joint and pain. Mechanical stress plays a central role in OA development. It is hypothesized that cells in the OA joints produce OA-promoting molecules upon mechanical stress, and therefore, the mechanosensing systems are a theoretical target for OA treatment. Piezo mechanosensing channels mediate high-level mechanical stress in chondr...

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Literature Corpus work: c1889fdd-03c9-5611-8554-14c5b813ca64
DOI: 10.1101/2022.10.07.511314

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