Pathobiology of Osteoarthritis: Pathomechanisms and Potential Therapeutic Targets

Abstract excerpt

Osteoarthritis, a degenerative joint disease, is the most disabling condition of the Western world. It affects first and foremost the articular cartilages and leads to a molecular and supramolecular destruction of the extracellular cartilage matrix. In addition, the cells, the chondrocytes, show severe alterations of their phenotype: they get anabolically and catabolically activated, change accordingly their gene...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Inflammatory mediators and NSAID effects
• Share to Osteoarthritis Treatment and Mechanisms