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Article

CITED2 mediates the cross‐talk between mechanical loading and IL‐4 to promote chondroprotection

19 Mar 2019

Abstract excerpt

Osteoarthritis (OA) pathogenesis is mediated largely through the actions of proteolytic enzymes such as matrix metalloproteinase (MMP) 13. The transcriptional regulator CITED2, which suppresses the expression of MMP13 in chondrocytes, is induced by interleukin (IL)-4 in T cells and macrophages, and by moderate mechanical loading in chondrocytes. We tested the hypothesis that CITED2 mediates cross-talk between...

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PMID: 30891766
DOI: 10.1111/nyas.14021

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