Article

Reducing oxidative stress improves ex vivo polymer-based human haematopoietic stem and progenitor cell culture and gene editing

2024-09-18

Abstract excerpt

Self-renewing multipotent haematopoietic stem cells (HSCs) have the unique capacity to stably regenerate the entire blood and immune systems following transplantation. HSCs are used clinically to reconstitute a healthy blood system in patients suffering from a range of haematological diseases. However, HSCs are very rare and have been challenging to grow ex vivo, which has hampered efforts to collect large numbers...

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Literature Corpus work: d7c55182-b3f3-5e62-a1c5-535eda6e572e
DOI: 10.1101/2024.09.17.613552

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