Article

Discovery of a Novel Polymer for Xeno-free, Long-term Culture of Human Pluripotent Stem Cell Expansion

2020-09-16

Abstract excerpt

Human pluripotent stem cells (hPSCs) can be expanded and differentiated in vitro into almost any adult tissue cell type, and thus have great potential as a source for cell therapies with biomedical application. In this study, a fully-defined polymer synthetic substrate is identified for hPSC culture in completely defined, xeno-free conditions. This system can overcome the cost, scalability and reproducibility lim...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1a2e01a3-a802-5973-abfc-da30d7a6ee42
DOI: 10.1101/2020.09.16.298810

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Discovery of a Novel Polymer for Xeno-free, Long-term Culture of Human Pluripotent Stem Cell ExpansionDOI 10.1101/2020.09.16.298810Read

Defined Essential 8™ Medium and Vitronectin Efficiently Support Scalable Xeno-Free Expansion of Human Induced Pluripotent Stem Cells in Stirred Microcarrier Culture SystemsSemantic proximity Read

Long-term expansion, genomic stability and in vivo safety of adult human pancreas organoidsSemantic proximity Read

Production of Human Pluripotent Stem Cell Therapeutics under Defined Xeno-free Conditions: Progress and ChallengesSemantic proximity Read

Xeno-free, chemically defined and scalable monolayer differentiation protocol for retinal pigment epithelial cellsSemantic proximity Read

Xeno-free, chemically defined and scalable monolayer differentiation protocol for retinal pigment epithelial cellsSemantic proximity Read

Synthetic substrates for long-term stem cell cultureSemantic proximity Read

Long-term expansion, genomic stability, in vivo safety and immunogenicity of adult human pancreas organoidsSemantic proximity Read

Self‐Assembling Proteins as High‐Performance Substrates for Embryonic Stem Cell Self‐RenewalSemantic proximity Read

Chemically defined and xenogeneic-free differentiation of human pluripotent stem cells into definitive endoderm in 3D cultureSemantic proximity Read

Polymer Supported Directed Differentiation Reveals a Unique Gene Signature Predicting Stable Hepatocyte PerformanceSemantic proximity Read

Xeno- and feeder-free differentiation of human pluripotent stem cells to two distinct ocular epithelial cell types using simple modifications of one methodSemantic proximity Read

Reducing oxidative stress improves ex vivo polymer-based human haematopoietic stem and progenitor cell culture and gene editingSemantic proximity Read